- Offred
- Dorothea Spilger
- The Double
- Clara Fréjacques
- Luke
- Michael Müller-Kasztelan
- Aunt Lydia
- Agnieszka Hauzer
- Moira
- Xenia Cumento
- Janine - Ofwarren
- Julie Hyunseo Lee
- Serena Joy
- Tatia Jibladze
- Rita
- Marta Swiderska
- The Commander
- Oleksandr Kharlamov
- Nick
- Konrad Furian
- Ofglen
- Heike Wittlieb
- The Doctor
- Cathal McCabe
- New Ofglen
- Elisabeth Raßbach-Külz, Mia Jakob
- Moira's Aunt
- Sarah Werneburg, Gabriele Vasiliauskaite
- Warren's Wife
- Ilka von Holtz, Emma McDermott
- Commander X
- Jeffrey Nardone, Theodor Valentin Iliescu
- Handmaid A1 and A Handmaid
- Jule-Katrin Burghardt, Hélène Rauch-Kosikidis
- Handmaid B1 and Echo
- Anka Perfanova, Monica Mhangwana
- Intimitätskoordiantion
- Franny Kromminga
- Offred's Mother
- Gudrun Pelker
- Eye and Guard 1
- Pavlo Aleksandrov